Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development
Identifieur interne : 005A36 ( Main/Exploration ); précédent : 005A35; suivant : 005A37Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development
Auteurs : Fei Zhou [République populaire de Chine] ; Zai Chang [République populaire de Chine] ; Luqing Zhang [République populaire de Chine] ; Young-Kwon Hong [États-Unis] ; Bin Shen [République populaire de Chine] ; Bo Wang [République populaire de Chine] ; Fan Zhang [République populaire de Chine] ; Guangming Lu [République populaire de Chine] ; Denis Tvorogov [Finlande] ; Kari Alitalo [Finlande] ; Brian A. Hemmings [Suisse] ; Zhongzhou Yang [République populaire de Chine] ; Yulong He [République populaire de Chine]Source :
- The American Journal of Pathology [ 0002-9440 ] ; 2010.
Abstract
Akt-mediated signaling plays an important role in blood vascular development. In this study, we investigated the role of Akt in lymphatic growth using Akt-deficient mice. First, we found that lymphangiogenesis occurred in
Url:
DOI: 10.2353/ajpath.2010.091301
PubMed: 20724596
PubMed Central: 2947305
Affiliations:
- Finlande, République populaire de Chine, Suisse, États-Unis
- Californie, Uusimaa
- Helsinki
- Université d'Helsinki
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<author><name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name>
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<front><div type="abstract" xml:lang="en"><p>Akt-mediated signaling plays an important role in blood vascular development. In this study, we investigated the role of Akt in lymphatic growth using Akt-deficient mice. First, we found that lymphangiogenesis occurred in <bold><italic>Akt1</italic>
</bold>
<sup>−/−</sup>
, <bold><italic>Akt2</italic>
</bold>
<sup>−/−</sup>
, and <bold><italic>Akt3</italic>
</bold>
<sup>−/−</sup>
mice. However, both the diameter and endothelial cell number of lymphatic capillaries were significantly less in <bold><italic>Akt1</italic>
</bold>
<sup>−/−</sup>
mice than in wild-type control mice, whereas there was only a slight change in <bold><italic>Akt2</italic>
</bold>
<sup>−/−</sup>
and <bold><italic>Akt3</italic>
</bold>
<sup>−/−</sup>
mice. Second, valves present in the small collecting lymphatics in the superficial dermal layer of the ear skin were rarely observed in <bold><italic>Akt1</italic>
</bold>
<sup>−/−</sup>
mice, although these valves could be detected in the large collecting lymphatics in the deep layer of the skin tissues. A fluorescence microlymphangiography assay showed that the skin lymphatic network in <bold><italic>Akt1</italic>
</bold>
<sup>−/−</sup>
mice was functional but abnormal as shown by fluorescein isothiocyanate-dextran draining. There was an uncharacteristic enlargement of collecting lymphatic vessels, and further analysis showed that smooth muscle cell coverage of collecting lymphatic vessels became much more sparse in <bold><italic>Akt1-</italic>
</bold>
deficient mice than in wild-type control animals. Finally, we showed that lymphatic vessels were detected in compound <bold><italic>Akt</italic>
</bold>
-null mice and that lymphangiogenesis could be induced by vascular endothelial growth factor-C delivered via adenoviral vectors in adult mice lacking <bold><italic>Akt1</italic>
</bold>
. These results indicate that despite the compensatory roles of other Akt isoforms, Akt1 is more critically required during lymphatic development.</p>
</div>
</front>
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<li>Suisse</li>
<li>États-Unis</li>
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<region><li>Californie</li>
<li>Uusimaa</li>
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<name sortKey="Zhang, Fan" sort="Zhang, Fan" uniqKey="Zhang F" first="Fan" last="Zhang">Fan Zhang</name>
<name sortKey="Zhang, Luqing" sort="Zhang, Luqing" uniqKey="Zhang L" first="Luqing" last="Zhang">Luqing Zhang</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Hong, Young Kwon" sort="Hong, Young Kwon" uniqKey="Hong Y" first="Young-Kwon" last="Hong">Young-Kwon Hong</name>
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<country name="Finlande"><noRegion><name sortKey="Tvorogov, Denis" sort="Tvorogov, Denis" uniqKey="Tvorogov D" first="Denis" last="Tvorogov">Denis Tvorogov</name>
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<name sortKey="Alitalo, Kari" sort="Alitalo, Kari" uniqKey="Alitalo K" first="Kari" last="Alitalo">Kari Alitalo</name>
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<country name="Suisse"><noRegion><name sortKey="Hemmings, Brian A" sort="Hemmings, Brian A" uniqKey="Hemmings B" first="Brian A." last="Hemmings">Brian A. Hemmings</name>
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</tree>
</affiliations>
</record>
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